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Population pharmacokinetics of paritaprevir ombitasvir dasabuvir ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials

机译：Paritaprevirombitasvirdasabuvirritonavir和ribavirin在1型肝炎病毒基因型1感染中的群体药代动力学：六项III期试验的分析

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摘要

AimThe aim of the current study was to characterize the population pharmacokinetics of a triple direct‐acting antiviral (DAA) regimen (3D) (ombitasvir, paritaprevir–ritonavir and dasabuvir) and adjunctive ribavirin, and estimate covariate effects in a broad spectrum of subjects with hepatitis C virus (HCV) genotype 1 infection.

机译：目的本研究的目的是表征三重直接作用抗病毒（DAA）方案（3D）（ombitasvir，paritaprevir–ritonavir和dasabuvir）和辅助性利巴韦林的人群药代动力学，并评估广泛的受试者的协变量效应丙型肝炎病毒（HCV）基因型1感染。

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期刊名称 British Journal of Clinical Pharmacology
作者
Sven Mensing; Doerthe Eckert; Shringi Sharma; Akshanth R. Polepally; Amit Khatri; Thomas J. Podsadecki; Walid M. Awni; Rajeev M. Menon; Sandeep Dutta;
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作者单位

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年(卷),期 2017(83),3
年度 2017
页码 527–539
总页数 13
原文格式 PDF
正文语种
中图分类药学 ;
关键词
3D regimen direct‐acting antivirals dosing recommendations HCV genotype 1 population pharmacokinetics;

机译：3D方案;直接作用抗病毒药;剂量建议;HCV基因型1;人群药代动力学;

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专利

1. Population pharmacokinetics of paritaprevir, ombitasvir, dasabuvir, ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials [J] . Mensing Sven, Eckert Doerthe, Sharma Shringi, British journal of clinical pharmacology . 2017 ,第3期

机译：Paritaprevir，ombitasvir，dasabuvir，ritonavir和ribavirin在C型肝炎病毒基因型1感染中的群体药代动力学：六项III期试验的分析
2. Population Pharmacokinetics of Paritaprevir, Ombitasvir, Dasabuvir, Ritonavir, and Ribavirin in Hepatitis C Virus-Infected Cirrhotic and Non-cirrhotic Patients: Analyses Across Nine Phase III Studies [J] . Sathej Gopalakrishnan, Sven Mensing, Rajeev M. Menon, Clinical pharmacokinetics . 2018 ,第11期

机译：ParitaPrevir，Obsbitasvir，Dasbuvir，Ritonavir和利巴韦林的人口药代动力学在丙型肝炎病毒感染的肝硬化和非肝硬化患者中的利巴韦林：分析九届III研究
3. Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With or Without Ribavirin in Patients With Chronic Hepatitis C Virus Genotype 1 Infection Receiving Opioid Substitution Therapy: A Post Hoc Analysis of 12 Clinical Trials [J] . Jason Grebely, Massimo Puoti, Heiner Wedemeyer, Open Forum Infectious Diseases . 2018 ,第11期

机译：Ombitasvir / Paritaprevir / Ritonavir和Dasabuvir联合或不联合利巴韦林在接受阿片类药物替代治疗的慢性丙型肝炎病毒基因型1感染患者中的疗效和安全性：对12项临床试验的事后分析
4. Influence of hepatitis C virus genotypes and F protein on outcome of HCV infection among injection drug users [C] . Yun Zhang, Jingjing Yang, Haopeng Wang, International symposium on pharmacogenomics and the regulation of drug metabolism enzymes and genes. . 2010

机译：丙型肝炎病毒基因型和F蛋白对注射吸毒者HCV感染结局的影响
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Population Pharmacokinetics of Paritaprevir Ombitasvir Dasabuvir Ritonavir and Ribavirin in Patients with Hepatitis C Virus Genotype 1 Infection: Combined Analysis from 9 Phase 1b/2 Studies [O] . Sven Mensing, Akshanth R. Polepally, Denise König, 2016

机译：丙型肝炎病毒基因型1感染患者中ParitaprevirOmbitasvirDasabuvirRitonavir和Ribavirin的群体药代动力学：9个1b / 2期研究的组合分析
7. Population pharmacokinetics of paritaprevir, ombitasvir, dasabuvir, ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials [O] . Sven Mensing, Doerthe Eckert, Shringi Sharma, 2016

机译：Paritaprevir，Obsbitasvir，Dasbuvir，Ritonavir和利巴韦林的人口药代动力学在丙型肝炎病毒基因型1感染1感染：六阶段III试验分析

Population pharmacokinetics of paritaprevir ombitasvir dasabuvir ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials

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