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Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs

机译：基于PCR的检测方法的开发和验证用于选择更可能受益于烷基化药物治疗的患者

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摘要

AIMIn order to develop and validate a simple, sensitive and rapid method for the quantitation of alkylating drug-induced DNA damage.

机译：目的开发和验证一种简单，灵敏和快速的方法，用于定量烷基化药物诱导的DNA损伤。

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期刊名称 British Journal of Clinical Pharmacology
作者
Dimitra T Stefanou; Hara Episkopou; Soterios A Kyrtopoulos; Aristotelis Bamias; Maria Gkotzamanidou; Christina Bamia; Christina Liakou; Margarita Bekyrou; Petros P Sfikakis; Meletios-Athanasios Dimopoulos; Vassilis L Souliotis;
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作者单位

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年(卷),期 2012(74),5
年度 2012
页码 842–853
总页数 12
原文格式 PDF
正文语种
中图分类药学 ;
关键词
alkylating drugs clinical outcome DNA adducts DNA repair multiplex quantitative PCR;

机译：烷基化药物;临床结果;DNA加合物;DNA修复;多重定量PCR;

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专利

1. Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs [J] . StefanouD.T., EpiskopouH., KyrtopoulosS.A., British Journal of Clinical Pharmacology . 2012 ,第5期

机译：基于PCR的检测方法的开发和验证，用于选择更可能受益于烷基化药物治疗的患者
2. Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs [J] . Dimitra T. Stefanou, Hara Episkopou, Soterios A. Kyrtopoulos, British journal of clinical pharmacology . 2012 ,第5期

机译：基于PCR的检测方法的开发和验证，用于选择更可能受益于烷基化药物治疗的患者
3. Development and validation of a PCR-based marker assay for negative selection of the HMW glutenin allele Glu-B1-1d (Bx-6) in wheat [J] . G. Schwarz, F. G. Felsenstein, G. Wenzel Theoretical and Applied Genetics . 2004 ,第5期

机译：小麦HMW谷蛋白等位基因Glu-B1-1d（Bx-6）阴性选择的基于PCR的标记试验的开发和验证
4. Statistic Evaluation of the Clinical Benefits of Rehabilitation in Patients with Spine Cord Injury Undergoing Complex Treatment with Specific Therapeutic Factors from Techirghiol Health Resort [C] . Advanced Technologies for Enhanced Quality of Life Meeting . 2009

机译：脊髓损伤患者康复临床益处的统计评价，其特异性治疗特异性治疗因素特异性治疗因素
5. Modification of two PCR-based assays for use in differentiating trichostrongyle eggs and their validation with naturally-infected calf fecal samples. [D] . Harmon, Aaron Floyd. 2006

机译：修改了两个基于PCR的检测方法，用于区分毛滴虫卵，并用天然感染的牛粪便样品进行了验证。
6. Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia [O] . Le-jing Lian, Bin Lin, Xiao Cui, 2020

机译：急性淋巴细胞白血病儿童高剂量甲氨蝶呤治疗药物监测的UHPLC-MS / MS测定的开发和验证
7. Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs. [O] . Stefanou, Dimitra T, Episkopou, Charikleia, Kyrtopoulos, Soterios A, 2012

机译：基于PCR的检测方法的开发和验证，用于选择更可能受益于烷基化药物治疗的患者。

Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs

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