The influence of guanfacine on blood pressure and lung function in hypertensive patients with chronic obstructive lung disease

摘要

>1 The effects of guanfacine, given once daily in dosages of 0.5-3 mg, on blood pressure and lung function were investigated in a placebo controlled single-blind trial in 10 patients with hypertension and chronic obstructive lung disease.>2 Six of the 10 patients also received a thiazide diuretic in an unchanged dose throughout the study.>3 Guanfacine lowered diastolic blood pressure to less than 95 mm Hg in 9/10 patients.>4 Lung function was not influenced by guanfacine.>5 A dry mouth was the most frequent side effect.