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Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

机译：基底样乳腺癌细胞中频繁的PTEN基因组改变和激活的磷脂酰肌醇3-激酶途径

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IntroductionBasal-like carcinomas (BLCs) and human epidermal growth factor receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that have the most aggressive clinical behaviour. In contrast to HER2+ carcinomas, no targeted therapy is currently available for the treatment of patients with BLCs. In order to discover potential therapeutic targets, we aimed to discover deregulated signalling pathways in human BLCs.

机译：简介基底样癌（BLC）和人类表皮生长因子受体2过表达（HER2 +）癌是临床行为最积极的乳腺癌亚组。与HER2 +癌症相反，目前尚无靶向疗法可用于治疗BLC患者。为了发现潜在的治疗靶标，我们旨在发现人类BLC中失控的信号传导途径。

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期刊名称 Breast Cancer Research : BCR
作者
Bérengère Marty; Virginie Maire; Eléonore Gravier; Guillem Rigaill; Anne Vincent-Salomon; Marion Kappler; Ingrid Lebigot; Fathia Djelti; Audrey Tourdès; Pierre Gestraud; Philippe Hupé; Emmanuel Barillot; Francisco Cruzalegui; Gordon C Tucker; Marc-Henri Stern; Jean-Paul Thiery; John A Hickman; Thierry Dubois;
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年(卷),期 2008(10),6
年度 2008
页码 R101
总页数 15
原文格式 PDF
正文语种
中图分类肿瘤学;
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专利

1. Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells [J] . Barengare Marty, Virginie Maire, Elaonore Gravier, Breast Cancer Research . 2008,第6期

机译：基底样乳腺癌细胞中频繁的PTEN基因组改变和激活的磷脂酰肌醇3-激酶途径
2. Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway. [J] . Han JK, Lee HS, Yang HM, Circulation: An Official Journal of the American Heart Association . 2008,第10期

机译：过氧化物酶体增殖物激活的受体-δ激动剂通过磷脂酰肌醇3-激酶/ Akt途径的基因组和非基因组激活来调节内皮祖细胞，从而增强了血管生成。
3. Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells [J] . PiresM.M., HopkinsB.D., SaalL.H., Cancer biology & therapy . 2013,第3期

机译：模仿基底样乳腺癌中发现的EGFR，p53和PTEN的改变促进了人类乳腺上皮细胞的转化
4. Multifaceted activities of class Ⅰ phosphatidylinositol 3-kinase inhibitor ZSTK474 on human breast cancer cells [C] . Xin Peng, Zhengming Wang, Chang Zhou, International Forum on Leading Edge Technologies on Crystallization Engineering and Pharmaceutics Development;Tianjin University;Tianjin Medical University . -1

机译：Ⅰ类磷脂酰肌醇3-激酶抑制剂ZSTK474对人乳腺癌细胞的多丝活动
5. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. The mechanism of activation of phosphatidylinositol 3-kinase [D] . Al-Shami, Amin 1998

机译：人类嗜中性粒细胞中的粒细胞-巨噬细胞集落刺激因子激活的信号通路。磷脂酰肌醇3-激酶的激活机制
6. ADP-ribosylation Factor 1 Controls the Activation of the Phosphatidylinositol 3-Kinase Pathway to Regulate Epidermal Growth Factor-dependent Growth and Migration of Breast Cancer Cells [O] . Pierre-Luc Boulay, Mathieu Cotton, Paul Melançon, 2008

机译：ADP-核糖基化因子1控制着ADP的激活磷脂酰肌醇3-激酶途径调节表皮生长乳腺癌的因子依赖性生长和迁移细胞
7. Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells [O] . Marty, Bérengère, Maire, Virginie, Gravier, Eléonore, 2008

机译：基底样乳腺癌细胞中频繁的PTEN基因组改变和激活的磷脂酰肌醇3-激酶途径

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

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