1. Afferent discharges were recorded from nerve filaments dissected from the hepatic branch of the vagus nerve in the guinea-pig in situ. 2. A significant decrease in the discharge rate was observed following the administration of D-glucose into the portal vein but not after the administration of D-mannose, D-fructose, D-galactose, L-glucose, D-xylose or D-arabinose. 3. The mean discharge rate of these fibres was inversely related to the concentration of glucose in the portal blood. 4. These results suggest the existence of D-glucose 'sensors' in the liver which monitor the glucose concentration of portal blood.
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