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Experimental infection of weanling pigs with A/Swine influenza virus

机译:断奶仔猪感染甲型/猪流感病毒的实验

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摘要

As part of a study described in a previous paper observations were made to determine whether and for how long experimentally infected young pigs would transmit their infection to new groups of weanlings maintained in contact with them. When groups of 4 or 5 susceptible weanlings 2-3 months old were placed in contact for a month with infected pigs 42 days or 3, 6, 9 or 12 months after experimental infection, no antibody rises were observed in the contact pigs. However, a strain of virus identical with the infecting strain was isolated from lung suspensions from 2 of the 5 contact pigs exposed to pigs infected 3 months previously. Possible sources of technical error such as laboratory contamination could be almost certainly excluded. It is considered that a shedder state of virus had occurred some time during the fourth month following experimental infection. There was suggestive serological evidence that the shed virus acted as a booster dose to previously infected pigs.
机译:作为先前论文中描述的研究的一部分,进行了观察以确定是否有实验感染的幼猪将其感染传播给与它们保持接触的新的断奶组以及持续多长时间。当将4或5个2-3个月大的易感断奶组与感染猪接触一个月,即实验感染后42天或3、6、9或12个月时,在接触猪中未观察到抗体升高。然而,从暴露于3个月前感染的猪的5只接触猪中的2只的肺悬浮液中分离出与感染株相同的病毒株。几乎可以肯定地排除了可能的技术错误来源,例如实验室污染。可以认为,在实验性感染后的第四个月内,病毒呈脱落状态。有暗示的血清学证据表明,该脱落病毒可作为先前感染猪的加强剂量。

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