1. Electrophysiological techniques were used to study the sacral parasympathetic pathway to the colon of the cat. 2. Electrical stimulation of the sacral ventral roots or the pelvic nerve elicited contractions of the colon and firing in nerve filaments on the serosal surface of the colon. Both responses were markedly reduced by the administration of ganglionic blocking agents. It is concluded that sacral preganglionic fibres to the colon make synaptic contacts with extramural ganglion cells. These cells were identified histologically in small ganglia on the serosal surface of the distal colon and rectum. 3. Transmission in extramural colonic ganglia was cholinergic and mediated by nicotinic receptors. Colonic ganglia did not exhibit large recruiting responses during repetitive (1-4 c/s) preganglionic nerve stimulation or an adrenergic inhibitory mechanism, both of which have been identified in bladder parasympathetic ganglia. It is concluded that colonic ganglia unlike bladder function primarily as simple relay stations and have little potential for modulating the neral activity arising in the central nervus system. 4. The preganglionic input to colonic ganglia was mediated by C fibres with maximal conduction velocities ranging from 0-5 to 1-4 m/sec. Bladder ganglia, on the other hand, received a preganglionic input composed of B fibres with maximal conduction velocities ranging from 8 to 10 m/sec. The possible physiological significance of different types of preganglionic fibres in the sacral outflow is discussed.
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机译:1.电生理技术被用来研究to骨副交感神经通向猫结肠的途径。 2.电刺激the腹根部或骨盆神经引起结肠收缩,并在结肠浆膜表面产生神经丝。施用神经节阻滞剂可明显降低两种反应。结论是to骨神经节前纤维到结肠与壁外神经节细胞发生突触接触。这些细胞在组织学上在远端结肠和直肠的浆膜表面的小神经节中被鉴定。 3.在壁外结肠神经节中的传播是胆碱能的,并由烟碱受体介导。结肠神经节在重复(1-4 c / s)神经节前神经刺激或肾上腺素抑制机制期间未表现出较大的募集反应,这两种现象均已在膀胱副交感神经节中发现。结论是,结肠神经节不像膀胱那样主要起简单的中继站的作用,并且几乎没有调节中央神经系统产生的神经活动的潜力。 4.结肠神经节的神经节前输入是由C纤维介导的,其最大传导速度为0-5至1-4 m / sec。另一方面,膀胱神经节接受由B纤维组成的神经节前输入,其最大传导速度为8至10 m / sec。 discussed骨流出中不同类型的神经节前纤维的可能的生理意义进行了讨论。
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