1. Local blood flow has been measured in the hypothalamus and other areas of the brain in the conscious rabbit, by measuring the rate of clearance of small volumes (2·5-10 μl.) of a saline solution of the inert tracer 133Xe injected locally.2. Increasing the arterial PCO2 caused a mean rise in the hypothalamic blood flow of 34%.3. The hypothalamic blood flow remained relatively constant over a mean arterial blood pressure range of 41-140 mm Hg.4. Hypothalamic blood flow was relatively unaffected by anaesthesia with intravenous pentobarbitone; by contrast, blood flow in the cerebral cortex was greatly reduced.5. It is concluded that the technique is a valid and useful one, since CO2 responsiveness and autoregulation is maintained. Different areas of grey matter have different flow rates, and vary in their responsiveness to barbiturate anaesthesia.
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机译:1.通过测量惰性示踪剂的小体积盐溶液(2·5-10μl)的清除率,测量了清醒兔子下丘脑和其他大脑区域的局部血流。 > 133 sup> Xe局部注入2。动脉PCO2增加导致下丘脑血流量平均增加34%。3。在41-140 mm Hg.4的平均动脉血压范围内,下丘脑的血流保持相对恒定。静脉注射戊巴比妥麻醉下下丘脑的血流相对不受影响。相比之下,大脑皮层的血流量大大减少了。5。结论是,该技术是一种有效且有用的技术,因为可以保持对CO2的响应和自动调节。灰质的不同区域具有不同的流速,并且它们对巴比妥酸盐麻醉的反应性也不同。
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