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A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer

机译：新的席夫碱配位铜（II）化合物诱导胃癌细胞凋亡并抑制肿瘤生长

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BackgroundGastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used in clinic for gastric cancer treatment but with toxic side effects and develops resistance. Anti-tumor properties of copper and its coordinated compounds have been explored intensively in recent years.

机译：背景技术与其他胃肠道癌症相比，胃癌是一种多因素疾病，显示出细胞学和结构异质性，使其具有治疗挑战性。顺铂通常在临床上用于胃癌的治疗，但具有毒副作用并会产生耐药性。近年来，对铜及其配位化合物的抗肿瘤性能进行了深入研究。

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期刊名称 Cancer Cell International
作者
Yan Xia; Xingkai Liu; Luping Zhang; Jinzhu Zhang; Chaoying Li; Nan Zhang; Hong Xu; Yan Li;
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作者单位

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年(卷),期 2019(19),-1
年度 2019
页码 81
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Schiff base copper coordination compound NF-κB Autophagy ROS;

机译：Schiff碱铜配位化合物;NF-κB;自噬;ROS;

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专利

1. 3-Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth [J] . Wang Ting-An, Zhang Xiao-Dong, Guo Xing-Yu, Oncology reports . 2016,第3期

机译：3-溴丙酮酸和柠檬酸钠靶向糖酵解，抑制survivin，并诱导线粒体介导的胃癌细胞凋亡，并抑制胃原位移植肿瘤的生长
2. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis [J] . Zhang Bin, Han Hongyan, Fu Shilong, Biochemical Pharmacology . 2016,第Null期

机译：脱氢effusol通过选择性诱导肿瘤抑制内质网应激和中度凋亡来抑制胃癌细胞的生长和致瘤性
3. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. [J] . Cho SD, Lee SO, Chintharlapalli Molecular pharmacology. . 2010,第3期

机译：亚甲基取代的二吲哚基甲烷在膀胱癌细胞中激活神经生长因子诱导的Bα诱导细胞凋亡并抑制肿瘤生长。
4. Total Paeony Glycoside Inhibits Tumor Growth and Induces Apoptosis in K562 Cells and in S180 Tumor-Bearing Mice [C] . Huiyu Xu, Yanmin Wu, Xiaoqing Luo, Information technology and agricultural engineering . 2011

机译：总Pa药苷抑制K562细胞和S180荷瘤小鼠的肿瘤生长并诱导其凋亡。
5. STUDIES INVOLVING SCHIFF BASES AND THEIR ZINC(II) COMPLEXES: I. EQUILIBRIA AND TRANSAMINATION RATES OF VITAMIN B SUB 6 COMPOUNDS. II. TRANSIMINATION KINETICS OF SALICYLALDEHYDE SCHIFF BASES [D] . FELTY, WAYNE LEE. 1971

机译：席夫夫碱及其锌（II）配合物的研究：I.维生素B Sub 6化合物的平衡和氨基转移率。二。水杨醛席夫酸酯基的跃迁动力学
6. New Difluoro Knoevenagel Condensates of Curcumin Their Schiff Bases and Copper Complexes as Proteasome Inhibitors and Apoptosis Inducers in Cancer Cells [O] . Subhash Padhye, Huanjie Yang, Abeda Jamadar, -1

机译：新的Difluoro Knoevenagel姜黄素席克群和铜复合物作为癌细胞中的蛋白酶体抑制剂和凋亡诱导剂
7. A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer [O] . Yan Xia, Xingkai Liu, Luping Zhang, 2019

机译：一种新的席夫基地协调铜（II）化合物诱导细胞凋亡并抑制胃癌中的肿瘤生长

A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer

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