This study assessed the intraoperative analgesic effects of intravenous lidocaine administered by a constant rate infusion (CRI) in surgical canine patients. A prospective, blinded, randomized study was designed with 2 treatment groups: A (lidocaine) and B (placebo), involving 41 dogs. All patients were premedicated with acepromazine and buprenorphine, induced with propofol and midazolam; anesthesia was maintained with isoflurane in oxygen. Group A received 2 mg/kg IV lidocaine immediately after induction, followed within 5 min by a CRI at 50 μg/kg/min. Group B received an equivalent volume of saline instead of lidocaine. Changes in heart rate and blood pressure during maintenance were treated by increasing CRI. Fentanyl was used as a supplemental analgesic when intraoperative nociceptive response was not controlled with the maximum dose of lidocaine infusion. There was a significantly lower use of supplemental intraoperative analgesia in the lidocaine than in the placebo group. Group B dogs had almost twice as high a risk of intraoperative nociceptive response as group A dogs.
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机译：这项研究评估了恒定剂量输注（CRI）对犬科动物的静脉注射利多卡因的术中镇痛效果。设计了一项前瞻性，盲目的随机研究，分为2个治疗组：A（利多卡因）和B（安慰剂），涉及41只狗。所有患者均接受丙泊酚和咪达唑仑诱导的醋丙嗪和丁丙诺啡治疗。用异氟烷在氧气中维持麻醉。诱导后，A组立即接受2 mg / kg IV利多卡因，然后在5分钟内以50μg/ kg / min的CRI接受。 B组接受等量的生理盐水代替利多卡因。通过增加CRI治疗维持期间的心率和血压变化。当使用最大剂量的利多卡因输注无法控制术中的伤害反应时，将芬太尼用作辅助镇痛剂。与安慰剂组相比，利多卡因的术中补充镇痛剂的使用率明显较低。 B组犬的术中伤害反应风险几乎是A组犬的两倍。
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