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An Assessment of Database-Validated microRNA Target Genes in Normal Colonic Mucosa: Implications for Pathway Analysis

机译：正常结肠黏膜中数据库验证的microRNA靶基因的评估：路径分析的意义。

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BACKGROUNDDetermination of functional pathways regulated by microRNAs (miRNAs), while an essential step in developing therapeutics, is challenging. Some miRNAs have been studied extensively; others have limited information. In this study, we focus on 254 miRNAs previously identified as being associated with colorectal cancer and their database-identified validated target genes.

机译：背景技术由microRNA（miRNA）调控的功能途径的确定，虽然是开发治疗方法的重要步骤，但具有挑战性。一些miRNA已被广泛研究。其他人的信息有限。在这项研究中，我们集中于254个先前鉴定为与大肠癌相关的miRNA及其数据库鉴定的靶基因。

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期刊名称 Cancer Informatics
作者
Martha L Slattery; Jennifer S Herrick; John R Stevens; Roger K Wolff; Lila E Mullany;
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作者单位

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年(卷),期 2017(16),-1
年度 2017
页码 1176935117716405
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Colon cancer miRNA functionality bias RNA-Seq;

机译：结肠癌;miRNA;功能;偏倚;RNA-Seq;

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专利

1. An Assessment of Database-Validated microRNA Target Genes in Normal Colonic Mucosa: Implications for Pathway Analysis [J] . Martha L Slattery, Jennifer S Herrick, John R Stevens, Cancer Informatics . 2017,第3期

机译：正常结肠黏膜中数据库验证的microRNA靶基因的评估：路径分析的含义。
2. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer [J] . Anthony V Nguyen, Micaela Martinez, Michael J Stamos, Cancer Management and Research . 2009,第4期

机译：一期临床试验的结果，该试验检查了植物来源的白藜芦醇和葡萄粉对结肠粘膜和结肠癌中Wnt通路靶基因表达的影响
3. Analysis of potential genes and pathways associated with the colorectal normal mucosa–adenoma–carcinoma sequence [J] . Zhuoxuan Wu, Zhen Liu, Weiting Ge, Cancer Medicine . 2018,第6期

机译：与大肠正常黏膜-腺瘤-癌序列相关的潜在基因和途径分析
4. Signal Pathway in Sinusitis, Polyps and Normal Nasal Mucosa through Bioinformatics Analysis on Differentially Expressed-Proteins [C] . Chen, Xuedong, Tang, Faqing, Sun, Hong International Conference on Biomedical Engineering and Informatics;BMEI '09 . 2009

机译：通过差异表达蛋白的生物信息学分析鼻窦炎，息肉和正常鼻黏膜的信号通路
5. Using imputed microRNA regulation based on weighted ranked expression and putative microRNA targets and analysis of variance to select microRNAs for predicting prostate cancer recurrence. [D] . Wang, Qi. 2014

机译：使用基于加权排名表达和推定的microRNA靶标的估算microRNA调控以及方差分析来选择可预测前列腺癌复发的microRNA。
6. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer [O] . Anthony V Nguyen, Micaela Martinez, Michael J Stamos, 2009

机译：一期临床试验的结果研究了植物来源的白藜芦醇和葡萄粉对结肠粘膜和结肠癌中Wnt通路靶基因表达的影响
7. An Assessment of Database-Validated microRNA Target Genes in Normal Colonic Mucosa: Implications for Pathway Analysis [O] . Martha L Slattery, Jennifer S Herrick, John R Stevens, 2017

机译：正常结肠粘膜中数据库验证microRNa靶基因的评估：对途径分析的启示

An Assessment of Database-Validated microRNA Target Genes in Normal Colonic Mucosa: Implications for Pathway Analysis

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