Crizotinib versus Chemotherapy in Asian Patients with ALK-Positive Advanced Non-small Cell Lung Cancer

机译：克唑替尼与化学疗法治疗ALK阳性晚期非小细胞肺癌亚洲患者

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PurposeCrizotinib has demonstrated superior progression-free survival (PFS) and objective response rates (ORRs) versus chemotherapy in previously treated and untreated patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC). We report the safety and efficacy of crizotinib in Asian subpopulations of two global phase III trials.

机译：目的在已治疗和未治疗的间变性淋巴瘤激酶（ALK）阳性的晚期非小细胞肺癌（NSCLC）的先前治疗和未经治疗的患者中，克里索替尼已证明具有优于化疗的无进展生存期（PFS）和客观缓解率（ORR）。我们在两个全球III期临床试验的亚洲亚人群中报告了克唑替尼的安全性和有效性。

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期刊名称 Cancer Research and Treatment : Official Journal of Korean Cancer Association
作者
Makoto Nishio; Dong-Wan Kim; Yi-Long Wu; Kazuhiko Nakagawa; Benjamin J. Solomon; Alice T. Shaw; Satoshi Hashigaki; Emiko Ohki; Tiziana Usari; Jolanda Paolini; Anna Polli; Keith D. Wilner; Tony Mok;
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作者单位

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年(卷),期 2018(50),3
年度 2018
页码 691–700
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Asia Carboplatin Cisplatin Crizotinib Non-small cell lung carcinoma Pemetrexed;

机译：亚洲;卡铂;顺铂;克唑替尼;非小细胞肺癌;培美曲塞;

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专利

1. Intracranial Efficacy of Crizotinib Versus Chemotherapy in Patients With Advanced ALK-Positive Non-Small-Cell Lung Cancer: Results From PROFILE 1014 [J] . Solomon Benjamin J., Cappuzzo Federico, Felip Enriqueta, Journal of Clinical Oncology . 2016,第24期

机译：克唑替尼与化疗对晚期ALK阳性非小细胞肺癌患者的颅内疗效：来自PROFILE 1014的结果
2. Crizotinib in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer versus chemotherapy as a first-line treatment [J] . Jianya Zhou, Jing Zheng, Xiaochen Zhang, BMC Cancer . 2018,第1期

机译：肝硬化患者患有促进的淋巴瘤激酶阳性晚期非小细胞肺癌与化疗为一线治疗
3. Results of PROFILE 1029, a Phase III Comparison of?First-Line Crizotinib versus Chemotherapy in?East Asian Patients with ALK -Positive Advanced Non–Small Cell Lung Cancer [J] . Yi-Long Wu, Shun Lu, You Lu, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2018,第10期

机译：概况1029的结果，III阶段对比较？第一线屈曲与化疗的ααα患者（ALK）高级晚期非小细胞肺癌
4. Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer [C] . Hua Xin, Zhenguo Han, Haibo Huang 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：培美曲塞与多西他赛单药化疗在未接受化疗的老年晚期非小细胞肺癌患者中的作用
5. Predictors of changes in health-related quality of life during chemotherapy in an advanced non-small cell lung cancer patient population [D] . Shallwani, Shirin Mehdi 2010

机译：非小细胞肺癌晚期患者化疗期间健康相关生活质量变化的预测因子
6. Crizotinib in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer versus chemotherapy as a first-line treatment [O] . Jianya Zhou, Jing Zheng, Xiaochen Zhang, 2018

机译：克唑替尼用于间变性间变性淋巴瘤激酶阳性晚期非小细胞肺癌患者的化疗与一线治疗
7. Crizotinib versus Chemotherapy in Asian Patients with ALK-Positive Advanced Non-small Cell Lung Cancer [O] . Makoto Nishio, Dong-Wan Kim, Yi-Long Wu, 2018

机译：克里齐替尼与化疗在亚洲患者的ALK阳性晚期非小细胞肺癌

Crizotinib versus Chemotherapy in Asian Patients with ALK-Positive Advanced Non-small Cell Lung Cancer

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