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美国卫生研究院文献>Cardiovascular Diabetology
>Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients
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Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients
BackgroundVascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. However, metformin’s effects in patients with diabetic VC have not previously been characterized. The present study investigated the association between metformin use and lower-limb arterial calcification in patients with type 2 diabetes and high cardiovascular risk.
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