Effect of vildagliptin a dipeptidyl peptidase 4 inhibitor on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats

摘要

BackgroundHeart failure with left ventricular (LV) hypertrophy is often associated with insulin resistance and inflammation. Recent studies have shown that dipeptidyl peptidase 4 (DPP4) inhibitors improve glucose metabolism and inflammatory status. We therefore evaluated whether vildagliptin, a DPP4 inhibitor, prevents LV hypertrophy and improves diastolic function in isoproterenol-treated rats.