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A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil

机译:多奈哌齐致横纹肌溶解继发急性肾功能衰竭的罕见病例

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摘要

Introduction. Acute renal failure (ARF) develops in 33% of the patients with rhabdomyolysis. The main etiologic factors are alcoholism, trauma, exercise overexertion, and drugs. In this report we present a rare case of ARF secondary to probably donepezil-induced rhabdomyolysis. Case Presentation. An 84-year-old male patient was admitted to the emergency department with a complaint of generalized weakness and reduced consciousness for two days. He had a history of Alzheimer's disease for one year and he had taken donepezil 5 mg daily for two months. The patient's physical examination revealed apathy, loss of cooperation, and decreased muscle strength. Laboratory studies revealed the following: urea: 128 mg/dL; Creatinine 6.06 mg/dL; creatine kinase: 3613 mg/dL. Donepezil was discontinued and the patient's renal function tests improved gradually. Conclusion. Rhabdomyolysis-induced acute renal failure may develop secondary to donepezil therapy.
机译:介绍。横纹肌溶解症患者中有33%发生急性肾衰竭(ARF)。主要病因是酗酒,外伤,运动过度和药物。在本报告中,我们介绍了罕见的继发于多奈哌齐诱发的横纹肌溶解的ARF病例。案例介绍。一名84岁的男性患者因全身无力和意识降低而入院急诊室,为期两天。他有阿尔茨海默氏病病史一年,每天服用多奈哌齐5mg,持续两个月。病人的身体检查显示无动于衷,失去合作和肌肉力量下降。实验室研究发现:尿素:128 mg / dL;肌酐6.06 mg / dL;肌酸激酶:3613 mg / dL。停用多奈哌齐,患者的肾功能检查逐渐改善。结论。横纹肌溶解引起的急性肾衰竭可能在多奈哌齐治疗后继发。

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