Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

机译：Abi1丢失通过激活EMT和非经典WNT信号传导驱动前列腺癌的发生

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BackgroundProstate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a member of WAVE complex and actin cytoskeleton regulator and adaptor protein, acts as tumor suppressor in prostate cancer but the role of ABI1 in EMT is not clear.

机译：背景技术前列腺癌的发展涉及多种机制，人们对此知之甚少，但指出上皮间质转化（EMT）是进展为转移性疾病的关键机制。 ABI1是WAVE复合物和肌动蛋白细胞骨架调节剂和衔接蛋白的成员，在前列腺癌中起着抑癌作用，但ABI1在EMT中的作用尚不清楚。

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期刊名称 Cell Communication and Signaling : CCS
作者
Disharee Nath; Xiang Li; Claudia Mondragon; Dawn Post; Ming Chen; Julie R. White; Anita Hryniewicz-Jankowska; Tiffany Caza; Vladimir A. Kuznetsov; Heidi Hehnly; Tamara Jamaspishvili; David M. Berman; Fan Zhang; Sonia H. Y. Kung; Ladan Fazli; Martin E. Gleave; Gennady Bratslavsky; Pier Paolo Pandolfi; Leszek Kotula;
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年(卷),期 2019(17),-1
年度 2019
页码 120
总页数 19
原文格式 PDF
正文语种
中图分类细胞生物学;
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专利

1. Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling [J] . Disharee Nath, Xiang Li, Claudia Mondragon, Cell Communication and Signaling . 2019,第1期

机译：ABI1损失通过激活EMT和非规范WNT信号传导驱动前列腺肿瘤内血
2. Activation of Wnt11 by Transforming Growth Factor-β Drives Mesenchymal Gene Expression through Non-canonical Wnt Protein Signaling in Renal Epithelial Cells [J] . Peng Zhang, Yi Cai, Abdul Soofi, The Journal of biological chemistry . 2012,第25期

机译：通过在肾上皮细胞中转化生长因子-β驱动间充质基因表达来激活WNT11。肾上皮细胞中的非规范WNT蛋白信号
3. TRP63/TP63 loss accelerates skin tumorigenesis through activation of Wnt/β-catenin signaling [J] . Senthilnath Lakshmanachetty, Velmurugan Balaiya, Linda K. Johnson, Journal of dermatological science . 2018,第3期

机译：TRP63 / TP63损失通过激活Wnt /β-catenin信号传导来加速皮肤肿瘤内血
4. Roughness Surface Modification Regulates Wnt Canonical and Non-canonical Signaling Pathways in HMCS [C] . Olivares-Navarrete R., Hyzy S.L., Schwartz Z., Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：粗糙度表面修饰调节HMCS中Wnt的规范和非规范信号通路
5. Non-canonical WNT signaling through ROR2 and VANGL2 in mammary gland development. [D] . Smith, Prestina M. 2017

机译：通过ROR2和VANGL2在乳腺发育中的非经典WNT信号传导。
6. Activation of Wnt11 by Transforming Growth Factor-β Drives Mesenchymal Gene Expression through Non-canonical Wnt Protein Signaling in Renal Epithelial Cells [O] . Peng Zhang, Yi Cai, Abdul Soofi, 2012

机译：通过转化生长因子-β激活Wnt11通过非典型Wnt蛋白信号传导在肾上皮细胞中驱动间质基因表达。
7. Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway [O] . Nan Gao, Baoguo Ye 2020

机译：Circ-Sox4通过海绵miR-1270驱动肺腺癌的肿瘤血肿和发育，调节Plagl2激活Wnt信号通路

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

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