Evolution of Anticoagulant and Antiplatelet Therapy: Benefits and Risks of Contemporary Pharmacologic Agents and Their Implications for Myonecrosis and Bleeding in Percutaneous Coronary Intervention

摘要

Periprocedural myonecrosis, as evidenced by elevated creatine kinase–myocardial bound (CK‐MB) levels, occurs in up to 25% of patients undergoing percutaneous coronary intervention (PCI) and has been linked with an increased risk of adverse short‐ and long‐term clinical outcomes. Such myonecrosis arises from three main pathophysiological mechanisms: procedure‐related complications, lesion‐specific characteristics (e.g., large thrombus burden, plaque volume), and patient‐specific characteristics (e.g., genetic predisposition, arterial inflammation). Periprocedural myonecrosis has not been definitively identified as the cause of postprocedural ischemic events, although agents that reduce or prevent thrombosis—including aspirin, thienopyridines, heparin, low‐molecular‐weight heparins, glycoprotein IIb/IIIa inhibitors, and direct thrombin inhibitors—have been shown to reduce the incidence of ischemic outcomes in this population, as have agents that reduce inflammation (aspirin, statins). At the same time, antithrombotic agents are known to increase the risk of bleeding and the use of transfusions, which have likewise been associated with worse outcomes in these patients. Thus, optimal management of patients undergoing PCI represents a balance between minimizing the risk of ischemic outcomes and simultaneously minimizing the risk of major bleeding. It may be that patients who have only minor, untreated postprocedural elevations in CK‐MB level (with no clinical or angiographic signs of ischemia) might have a better prognosis than patients who have normal CK‐MB levels but who suffer major bleeding complications. Copyright © 2007 Wiley Periodicals, Inc.