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Impact of contrast echocardiography on diagnostic algorithms: Pharmacoeconomic implications

机译:对比超声心动图对诊断算法的影响:药物经济学意义

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摘要

The major goal of medicine in the era of managed care is to control escalating costs and to attain a high level of quality health care. Capitation has limited access to expensive and unnecessary testing, placing an emphasis on the prudent use of available technology. A vast armamentarium of available diagnostic screening tests are available within cardiology. Routine two‐dimensional (2‐D) echocardiography is a high‐quality, low‐cost test that provides enhanced portability and real‐time test interpretation over other noninvasive test modalities. The echocardiogram may cost up to 50% less than competitive nuclear single‐photon emission computed tomography (SPECT) imaging. However, on average 10% of routine and 33% of stress echocardiograms are suboptimal (disproportionately affecting obese patients and those with lung disease). Myocardial contrast echocardiography has been shown to provide enhanced endocardial border delineation and left ventricular opacification, to enhance Doppler signal, and to provide information on myocardial perfusion. In several recent phase II and III studies, the use of a contrast agent has been shown to improve the diagnostic accuracy of echocardiography substantially. Improvements in the diagnostic capabilities of echocardiography have been shown to (1) impact upon downstream repetitive testing in patients with an initially nondiagnostic echocardiogram, (2) potentially increase laboratory throughput, and (3) reduce the rate of false‐positive and negative tests as a result of improved image quality. As clinical and cost‐effectiveness parallel one another, the use of myocardial contrast echocardiography in selected patient cohorts will result in improved diagnostic accuracy and a cost‐effective pattern of care.
机译:在管理式医疗时代,医学的主要目标是控制不断上涨的成本并获得高质量的医疗服务。人为限制了进行昂贵且不必要的测试的机会,从而强调了对可用技术的谨慎使用。心脏病学范围内有大量可用的诊断筛查测试设备。常规的二维(2-D)超声心动图检查是一种高质量,低成本的检查,与其他无创检查方法相比,它具有更高的便携性和实时检查结果。超声心动图的成本可能比竞争性核单光子发射计算机断层扫描(SPECT)成像便宜50%。然而,平均而言,常规超声心动图的10%和压力超声心动图的33%是次优的(对肥胖患者和患有肺病的患者的影响不成比例)。心肌造影超声心动图已显示可增强心内膜边界轮廓和左心室混浊,增强多普勒信号,并提供有关心肌灌注的信息。在最近的一些II和III期研究中,已显示使用造影剂可显着提高超声心动图的诊断准确性。超声心动图的诊断能力的提高已显示出:(1)对最初没有诊断性超声心动图的患者的下游重复测试产生影响;(2)可能增加实验室通量;(3)降低假阳性和阴性测试的发生率,因为图像质量提高的结果。由于临床和成本效益相互平行,因此在选定的患者队列中使用心肌对比超声心动图将提高诊断准确性,并提供具有成本效益的护理模式。

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