Colchicine-Induced Rhabdomyolysis: Clinical Biochemical andNeurophysiological Features and Review of the Literature

摘要

We report the case of a 46-years-old man with long-term asymptomatic hyperuricemia who started taking colchicine (0.5 mg/day) and allopurinol (100 mg/d) for normalization of biochemical values. After the third week of starting treatment, acute weakness was present; and by the fifth week, profound weakness in lower extremities and tenderness and cramps on thighs and calves with inability to climb stairs were also observed. Biochemical evaluation showed elevated muscle enzymes (creatinine kinase [CK] raised to five-folds its normal value) and electromyographic features were consistent with myopathy (at rest, fibrillations, positive sharp waves, high-frequency myotonic discharges; motor unit action potentials [MUAPs] of small amplitude, small duration, increased polyphasic Index and occasional satellite potentials; at maximal effort, interferential recruitment pattern with reduced amplitudes were observed). Normal motor and sensitive nerve conduction studies and normal late F-responses and H-reflex discarded neuropathy. Rapid improvement in muscle strength and prompt resolution of abnormal elevated muscle enzymes was observed after withdrawal of both medications. Colchicine is associated with some cases of myotoxicity but verysmall cases of colchicine-induced rhabdomyolysis are reported on the literature.Colchicine-induced rhabdomyolysis is related to the concomitant use of drugs(statins, steroids, erythromycin, and cyclosporine), renal, and/or hepaticimpairment. To the best of our knowledge, this is an uncommon presentation of acase of colchicine-induced rhabdomyolysis reported in a patient without renal orhepatic dysfunction. Therefore, patients receiving colchicine even in theabsence of renal insufficiency should be monitored for the development ofmyopathy and more rarely to rhabdomyolysis.