In vitro spleen leucocyte migration and phytohaemagglutinin-stimulated lymphocyte transformation of immunosuppressed mice cells. I. Cells from mice treated by thymectomy and/or rabbit anti-mouse lymphocyte serum

摘要

An in vitro study of spleen leucocyte migration ability and phytohaemagglutinin (PHA) stimulated peripheral lymphocyte transformation response was made on cells derived from mice treated by thymectomy, thymectomy and/or rabbit anti-mouse lymphocyte serum (RAMLS). These responses were compared with those shown by normal mice and found to be considerably depressed. Thymectomy combined with RAMLS treatment produced the greatest change. This decreased activity persisted for up to 100 days. The spleen leucocyte migration results changed in parallel with the PHA-stimulated lymphocyte response and were considered to reflect a T-cell function.