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Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors

机译：通过诱导IPC祖细胞中PDX1和NKX6.1因子的表达来改善人iPSC向胰岛素产生细胞的定向分化

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摘要

BackgroundInduced pluripotent stem cells (iPSC) possess an enormous potential as both, scientific and therapeutic tools. Their application in the regenerative medicine provides new treatment opportunities for numerous diseases, including type 1 diabetes. In this work we aimed to derive insulin producing cells (IPC) from iPS cells established in defined conditions.

机译：背景技术诱导的多能干细胞（iPSC）作为科学和治疗工具均具有巨大潜力。它们在再生医学中的应用为包括1型糖尿病在内的多种疾病提供了新的治疗机会。在这项工作中，我们旨在从在确定条件下建立的iPS细胞衍生胰岛素产生细胞（IPC）。

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期刊名称 Journal of Translational Medicine
作者
Maciej P. Walczak; Anna M. Drozd; Ewelina Stoczynska-Fidelus; Piotr Rieske; Dawid P. Grzela;
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作者单位

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年(卷),期 2016(14),-1
年度 2016
页码 341
总页数 16
原文格式 PDF
正文语种
中图分类医学史;
关键词
Defined culture conditions Diabetes Differentiation Induced pluripotent stem cells Insulin producing cells NKX6.1 PDX1 Reprogramming;

机译：确定的培养条件;糖尿病;分化;诱导多能干细胞;产生胰岛素的细胞;NKX6.1;PDX1;重新编程;

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1. Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors [J] . Maciej P. Walczak, Anna M. Drozd, Ewelina Stoczynska-Fidelus, Journal of Translational Medicine . 2016,第1期

机译：通过诱导IPC祖细胞中PDX1和NKX6.1因子的表达来改善人iPSC向胰岛素产生细胞的定向分化
2. The combined expression of Pdx1 and MafA with either Ngn3 or NeuroD improves the differentiation efficiency of mouse embryonic stem cells into insulin-producing cells [J] . XuH., TsangK.S., ChanJ.C.N., Cell transplantation . 2013,第1期

机译：Pdx1和MafA与Ngn3或NeuroD的联合表达提高了小鼠胚胎干细胞向胰岛素产生细胞的分化效率
3. Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters [J] . So Young Chun, David L. Mack, Emily Moorefield, Journal of tissue engineering and regenerative medicine . 2015,第5期

机译：Pdx1和受控的培养条件诱导人羊水来源的干细胞向胰岛素生成簇的分化
4. Transcriptome (RNA-seq) analysis of human salivary gland cells with exogenous expression of human pancreas beta cells transcription factors PDX1, MAFA, NGN3 [C] . Olga Brovkina, Yulia Kolesova, Mikhail Borisov, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：外源表达人胰腺β细胞转录因子PDX1，MAFA，NGN3的人唾液腺细胞的转录组（RNA-seq）分析
5. Expansion and directed differentiation of human pluripotent stem cells to insulin-producing cells in a stirred-suspension microcarrier system. [D] . Lock, Lye Theng. 2011

机译：在搅拌悬浮微载体系统中将人多能干细胞扩增并定向分化为产生胰岛素的细胞。
6. Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters [O] . So Young Chun, David L. Mack, Emily Moorefield, -1

机译：PDX1和受控培养条件诱导人羊水衍生的干细胞的分化为胰岛素 - 产生簇的簇
7. Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors [O] . Maciej P. Walczak, Anna M. Drozd, Ewelina Stoczynska-Fidelus, 2016

机译：通过诱导IPC祖细胞中PDX1和NKX6.1因子的表达来改善人iPSC向胰岛素产生细胞的定向分化

Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors

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