The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury

摘要

IntroductionAcute lung injury (ALI) is an inflammatory disorder of pulmonary or extrapulmonary origin. We have previously demonstrated that netrin-1 dampens murine ALI, and in an attempt to advance this finding into future clinical practice we evaluated whether netrin-1 would reduce alveolar inflammation during porcine ALI.