Untargeted Metabolomics Analysis of Maternal Plasma from Pregnant C57Bl/6J Mice Identifies Significant Metabolic Changes in Response to Gestational Alcohol Exposure (OR26-01-19)

摘要

ObjectivesPrenatal alcohol exposure (PAE) affects 8% of U.S. pregnancies and causes persistent growth and neurodevelopmental deficits diagnosed as fetal alcohol spectrum disorders. Clinical trials using prenatal nutritional interventions can mitigate these neurobehavioral deficits. However, these studies are haphazard, because we do not understand how PAE alters nutrient needs and metabolite flux in the mother-child dyad. To address this knowledge gap, we used untargeted metabolomics to identify biochemical features that are significantly altered by PAE.