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Data on social transmission of food preference in a model of autism induced by valproic acid and translational analysis of circulating microRNA

机译:丙戊酸诱发的自闭症模型中食物偏好的社会传递数据和循环microRNA的翻译分析

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摘要

This article contains data of Social Transmission of Food Preference in an animal model of autism and the evaluation of a set of microRNA analyzed in autistic patients and animal model of autism. The analyses of the absolute consumption of two flavored food by male rats prenatally exposed to valproic acid (VPA) and treated with resveratrol (RSV), showed that VPA animals show a trend to eat less of the flavored food presented by a demonstrator rat. We also identified 13 microRNA with similar levels among rodents’ experimental groups, as well as 11 microRNA with no alterations between autistic and control subjects. Further evaluation of mechanisms of VPA and RSV actions on behavioral and molecular alterations can shed light in important biomarkers and etiological triggers of autistic spectrum disorders.
机译:本文包含自闭症动物模型中食物偏好的社会传播数据,以及对自闭症患者和自闭症动物模型中一组microRNA的评估。对产前暴露于丙戊酸(VPA)并用白藜芦醇(RSV)处理的雄性大鼠对两种调味食品的绝对消耗量的分析表明,VPA动物表现出趋向于减少示范鼠所提供的调味食品的趋势。我们还在啮齿动物的实验组中鉴定出了13种类似水平的microRNA,以及自闭症和对照组之间没有变化的11种microRNA。 VPA和RSV作用于行为和分子改变的机制的进一步评估可以揭示自闭症谱系障碍的重要生物标志物和病因。

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