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Data supporting that miR-92a suppresses angiogenic activity of adipose-derived mesenchymal stromal cells by down-regulating hepatocyte growth factor

机译:数据支持miR-92a通过下调肝细胞生长因子来抑制脂肪来源的间充质基质细胞的血管生成活性

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摘要

This article contains the full list of miRNAs expressed in cultured mesenchymal stromal cells, which were isolated from human adipose tissue. We provide here data regarding the effect of miR-92a overexpression on MSCs viability and cellular content of HGF and angiopoietin-1. These are followed by the data regarding the effect of conditioned medium of MSC transfected with pre-miR-92a, anti-miR-92a or scramble oligos on HUVEC viability as well as their tube formation efficiency. We also demonstrate here data regarding the effect of extracellular vesicle depletion from MSCs conditioned medium on its ability to stimulate the tube formation by HUVEC. Data interpretation and discussion can be found in Kalinina et al. (2015) .
机译:本文包含在培养的间充质基质细胞中表达的miRNA的完整列表,这些细胞是从人脂肪组织中分离出来的。我们在这里提供有关miR-92a过表达对MSC生存力以及HGF和血管生成素1细胞含量的影响的数据。这些数据之后是关于用pre-miR-92a,抗miR-92a或加扰寡核苷酸转染的MSC条件培养基对HUVEC生存力及其管形成效率的影响的数据。我们在这里还证明了有关从MSCs条件培养基中去除细胞外囊泡对其HUVEC刺激管形成能力的影响的数据。数据解释和讨论可以在Kalinina等人的文章中找到。 (2015)。

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