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Cysteine peptidase and its inhibitor activity levels and vitamin E concentration in normal human serum and colorectal carcinomas

机译:正常人血清和结肠直肠癌中的半胱氨酸肽酶及其抑制剂活性和维生素E浓度

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摘要

AIM: Cysteine peptidase (CP) and its inhibitor (CPI) are a matrix protease that may be associated with colorectal carcinoma invasion and progression, and vitamin E is also a stimulator of the immunological system. Our purpose was to determine the correlation between the expression of cysteine peptidases and their endogenous inhibitors, and the level of vitamin E in sera of patients with colorectal cancer in comparison with healthy individuals.METHODS: The levels of cysteine peptidases and their inhibitors were determined in the sera of patients with primary and metastatic colorectal carcinoma and healthy individuals using fluorogenic substrate, and the level of vitamin E was determined by HPLC.RESULTS: The levels of cysteine peptidases and their inhibitors were significantly higher in the metastatic colorectal cancer patients than that in the healthy controls (P<0.05). The activity of CP increased 2.2-fold, CPI 2.8-fold and vitamin E decreased 3.4-fold in sera of patients with metastasis in comparison with controls. The level of vitamin E in healthy individuals was higher, whereas the activity of cysteine peptidases and their inhibitors associated with complexes was lower than that in patients with cancer of the digestive tract.CONCLUSION: These results suggest that the serum levels of CP and their inhibitors could be an indicator of the prognosis for patients with metastatic colorectal cancer. Vitamin E can be administered prophylactically to prevent digestive tract neoplasmas.
机译:目的:半胱氨酸肽酶(CP)及其抑制剂(CPI)是一种基质蛋白酶,可能与大肠癌的侵袭和发展有关,维生素E也是免疫系统的刺激物。我们的目的是确定与健康个体相比大肠癌患者血清中半胱氨酸肽酶及其内源性抑制剂的表达与维生素E水平之间的相关性。方法:测定半胱氨酸肽酶及其抑制剂的水平结果:转移性大肠癌患者的半胱氨酸肽酶及其抑制剂的水平明显高于正常人和健康人的血清。荧光水平测定了维生素E的水平。健康对照组(P <0.05)。与对照组相比,转移患者血清中CP的活性增加了2.2倍,CPI增加了2.8倍,维生素E减少了3.4倍。健康人体内的维生素E含量较高,而半胱氨酸肽酶及其抑制剂与复合物相关的活性低于消化道癌患者。结论:这些结果表明,血清中CP及其抑制剂的水平可能是转移性结直肠癌患者预后的指标。可以预防性地服用维生素E,以预防消化道肿瘤。

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