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Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA

机译：来自单纯疱疹病毒1型衍生载体的针对人乳头瘤病毒16型E7 mRNA的反义RNA在CaSki细胞中表达并下调E7 mRNA

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BackgroundHuman papillomavirus (HPV) infection is known to be the most important etiologic factor of cervical cancer. There is no HPV specific therapy available for treatment of invasive squamous cell carcinoma of the cervix and its precursor lesions. The present study elucidates the potential to use herpes simplex virus (HSV) derived vectors for expression of antisense RNA to HPV -16 E7 oncogene.

机译：背景人类乳头瘤病毒（HPV）感染是宫颈癌的最重要病因。没有HPV特异性疗法可用于治疗宫颈浸润性鳞状细胞癌及其前体病变。本研究阐明了使用单纯疱疹病毒（HSV）衍生的载体表达针对HPV -16 E7癌基因的反义RNA的潜力。

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期刊名称 Virology Journal
作者
Ilkka Kari; Stina Syrjänen; Bo Johansson; Piritta Peri; Bin He; Bernard Roizman; Veijo Hukkanen;
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年(卷),期 2007(4),-1
年度 2007
页码 47
总页数 11
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒） ; 病毒（滤过性病毒） ;
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专利

1. 人乳头瘤病毒16型E6、E7反义RNA对人宫颈癌SiHa细胞的恶性逆转作用 [J] . 司马妮, 王薇, 徐茜, 癌症（英文版） . 2007 ,第001期
2. Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA [J] . Ilkka Kari, Stina Syrj?nen, Bo Johansson, Virology Journal . 2007 ,第1期

机译：来自单纯疱疹病毒1型衍生载体的针对人乳头瘤病毒16型E7 mRNA的反义RNA在CaSki细胞中表达并下调E7 mRNA
3. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. [J] . Jeon S, Lambert PF Proceedings of the National Academy of Sciences of the United States of America . 1995 ,第5期

机译：将人类乳头瘤病毒16型DNA整合到人类基因组中会导致E6和E7 mRNA的稳定性提高：对子宫颈癌的影响。
4. Purified herpes simplex type 1 glycoprotein D (gD) genetically fused with the type 16 human papillomavirus E7 oncoprotein enhances antigen-specific CD8+ T cell responses and confers protective antitumor immunity. [J] . Porchia BF, Diniz MO, Cariri FA, Molecular pharmaceutics . 2011 ,第6期

机译：与16型人乳头瘤病毒E7癌基因遗传融合的纯化的单纯性1型疱疹糖蛋白D（gD）可增强抗原特异性CD8 + T细胞反应并赋予保护性抗肿瘤免疫力。
5. Expression of platelet type 12 -lipoxygenase mRNA, integrin αVmRNA and their correlation with angiogenesis in esophageal squamous cell carcinoma [C] . First Zhengzhou International Oncology Congress（ZIOC）- An Update on Diagnosis and Treatment of Solid Tumors, 2005 . 2005

机译：食管鳞癌中血小板12型脂氧合酶mRNA，整合素αVmRNA的表达及其与血管生成的关系
6. Human papillomavirus type 16 E6 and E7 oncogene expression in relation to host cell growth and differentiation. [D] . Choo, Chee Keong. 1994

机译：人乳头瘤病毒16型E6和E7癌基因表达与宿主细胞生长和分化有关。
7. Epidermal growth factor (EGF) elicits down-regulation of human papillomavirus type 16 (HPV-16) E6/E7 mRNA at the transcriptional level in an EGF-stimulated human keratinocyte cell line: functional role of EGF-responsive silencer in the HPV-16 long control region. [O] . S Yasumoto, A Taniguchi, K Sohma 1991

机译：表皮生长因子（EGF）在EGF刺激的人角质形成细胞系中在转录水平引起人类乳头瘤病毒16型（HPV-16）E6 / E7 mRNA的下调：EGF响应性沉默子在HPV-16中的功能作用控制区域长。
8. Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA [O] . Ilkka Kari, Stina Syrjänen, Bo Johansson, 2007

机译：来自单纯疱疹病毒1型衍生载体的针对人乳头瘤病毒16型E7 mRNA的反义RNA在CaSki细胞中表达并下调E7 mRNA

Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA

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