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Mechanisms of Asthma and Allergic Inflammation: 504 Participation of Invariant NKT Cells (Vα24Jα18) during Asthma Exacerbation in Children

机译：哮喘和过敏性炎症的机制：504儿童哮喘急性发作期间不变NKT细胞（Vα24Jα18）的参与

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BackgroundInvariant NKT cells (or type 1 NKT cells) co-express CD3 marker and NK receptors (CD56, CD161) and use a single type of TCRα chain (Vα24Jα18 for humans), comprising CD4-CD8-, CD4+ and CD8+ subsets. Participation of these cells and their cytokines in asthmatic children, in stable conditions and under exacerbation, was studied.

机译：背景不变的NKT细胞（或1型NKT细胞）共同表达CD3标志物和NK受体（CD56，CD161），并使用单一类型的TCRα链（人为Vα24Jα18），包括CD4-CD8-，CD4 +和CD8 +亚群。研究了这些细胞及其细胞因子在哮喘患儿中的稳定状态和恶化情况。

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期刊名称 The World Allergy Organization Journal
作者
Juan Carlos Carpio-Pedroza; Blanca Estela del Rio-Navarro; Jaime Mariano del Río-Chivardí; Amelia Morales-Flores; Luis Antonio Jiménez-Zamudio; Martha Moreno-Lafont; Sigifredo Pedraza-Sánchez; Juan Gilberto Vaughan-Figueroa; Alejandro Escobar-Gutiérrez;
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年(卷),期 2012(5),Suppl 2
年度 2012
页码 S177
总页数 2
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专利

1. Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma. [J] . Zhang G, Nie H, Yang J, American Journal of Physiology . 2011,第6parta1期

机译：硫酸异化的II型NKT细胞通过在哮喘小鼠模型中抑制I型NKT细胞功能来防止过敏气道炎症。
2. Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma. [J] . Zhang G, Nie H, Yang J, American Journal of Physiology . 2011,第6parta1期

机译：硫酸异化的II型NKT细胞通过在哮喘小鼠模型中抑制I型NKT细胞功能来防止过敏气道炎症。
3. Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma. [J] . Zhang G, Nie H, Yang J, American Journal of Physiology . 2011,第6parta1期

机译：硫酸盐激活的II型NKT细胞通过抑制哮喘小鼠模型中的I型NKT细胞功能来预防过敏性气道炎症。
4. Acute Associations between PM2.5 and Allergic and Nonallergic Asthma Exacerbations in Children and Adults [C] . Natalie A. Rosenquist, Jim Metcalf, Gai Elhanan, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：PM2.5与儿童和成人过敏性和非过敏性哮喘急性发作之间的急性关联
5. Mechanisms of adenosine -mediated bronchoconstriction and inflammation in an allergic mouse model of asthma [D] . Oldenburg, Peter J. 2005

机译：腺苷介导的哮喘小鼠模型支气管收缩和炎症的机制
6. Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/− regulatory T cells in allergic asthma [O] . Khoa D. Nguyen, Chris Vanichsarn, Kari C. Nadeau -1

机译：变应性哮喘中CD4 +不变NKT细胞对CD4 + CD25hiCD127lo /-调节性T细胞的细胞毒性增加
7. Production of both IL-27 and IFN-g after the treatment with a ligand for invariant NKT cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model [O] . Fujita, H, Teng, A, Nozawa, R, 2009

机译：用不变的NKT细胞配体处理后，IL-27和IFN-g的产生可抑制小鼠实验性哮喘模型中的Th2反应和过敏性炎症

Mechanisms of Asthma and Allergic Inflammation: 504 Participation of Invariant NKT Cells (Vα24Jα18) during Asthma Exacerbation in Children

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