BackgroundThe World Allergy Organization estimates 520 million people with food allergy on the world. The data that support the prevalence fluctuate in relation of the method employed to obtain these, for example, questionnaires, measurements of IgE-specific, oral challenges; the last one is considerate the gold standard. Similar situation occur to allergy to cow´s milk (CMA), the prevalence reported is 1 to 17.5% in preschoolers, 1 to 13.5% in 5 to 16-year-olds, and 1 to 4% in adults. About 40% of infants referred for specialist management of Gastroesophageal Reflux Disease (GERD) have CMA. This situation increases to 56% in severe cases. These allergic reactions are typically not IgE-mediated. The gold standard for GERD is the pH measurement in 24 hours (specificity 100%), exist other test more accessible, with considerable sensivity (80%) like scintigraphy.
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