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A Novel Natural Product KL-21 Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells

机译：新型天然产物KL-21抑制增殖并诱导慢性淋巴细胞白血病细胞凋亡。

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摘要

Objective:The aims of this study were to examine the cytotoxic and apoptotic effects of KL-21, a novel plant product (produced by Naturin Natural Products, İzmir, Turkey), on 232B4 chronic lymphocytic leukemia (CLL) cells and to determine the cytotoxic effects on healthy BEAS-2B human bronchial epithelial cells.

机译：目的：本研究的目的是研究新型植物产品KL-21（由土耳其伊兹密尔的Naturin Natural Products生产）对232B4慢性淋巴细胞白血病（CLL）细胞的细胞毒性和凋亡作用，并确定其细胞毒性对健康的BEAS-2B人支气管上皮细胞的影响

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期刊名称 Turkish Journal of Hematology
作者
Aysun Adan Gökbulut; Mustafa Yaşar; Yusuf Baran;
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作者单位

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年(卷),期 2015(32),2
年度 2015
页码 118–126
总页数 9
原文格式 PDF
正文语种
中图分类血液学检验;
关键词
apoptosis Cell cycle arrest Chronic lymphocytic leukemia KL-21;

机译：细胞凋亡;细胞周期停滞;慢性淋巴细胞白血病;KL-21;

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专利

1. A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells [J] . Aysun Adan G?kbulut, Mustafa Ya?ar, Yusuf Baran Turkish Journal of Hematology . 2015,第2期

机译：新型天然产物KL-21抑制慢性淋巴细胞白血病细胞的增殖并诱导其凋亡。
2. Retraction: Beta-aescin: a potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro. [J] . Niu YP, Li LD, Wu LM Leukemia and lymphoma . 2009,第6期

机译：缩回：β-七叶皂苷：有效的天然抑制剂，可在人类慢性粒细胞白血病K562细胞中增殖和诱导细胞凋亡。
3. Beta-aescin: a potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro. [J] . Niu YP, Li LD, Wu LM Leukemia and lymphoma . 2008,第7期

机译：β-七叶皂苷：一种有效的天然天然抑制人慢性髓性白血病K562细胞增殖和凋亡的诱导剂。
4. Proteomics-based target deconvolution of clinical multi-kinase inhibitors inducing apoptosis in primary chronic lymphocytic leukemia cells (CLL) [C] . Marcus Bantscheff, Ulrich Kruse, Christian P. Pallasch, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：基于蛋白质组学的临床多激酶抑制剂诱导肾凋亡凋亡的靶碎屑（CLL）
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells [O] . Anna Parente-Ribes, Sigrid S. Skånland, Simone Bürgler, 2016

机译：脾酪氨酸激酶抑制剂可降低CD40L诱导的慢性淋巴细胞白血病细胞的增殖但不能降低正常B细胞的增殖
7. A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells [O] . Aysun Adan Gökbulut, Mustafa Yaşar, Yusuf Baran 2015

机译：新型天然产物KL-21抑制慢性淋巴细胞白血病细胞增殖并诱导细胞凋亡

A Novel Natural Product KL-21 Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells

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