Research on longevity is important to both prolong lifespan and support healthy aging. Natural products are widely being utilized and used as new resources for drug molecules. Caenorhabditis elegans is an advantageous organism for longevity research and age-related diseases. In this study, we tested a number of plant extracts for their effects on C. elegans longevity. In lifespan assays, agesynchronized wild-type C. elegans specimens were treated with different concentrations of plant extracts. Plant extracts were prepared as either infusions or decoctions, similar to their traditional utilization. Hedera helix L. (Araliaceae) extended lifespan in worms in a concentration-dependent manner. The mean survival rates in the H. helix-treated groups were significantly higher, by 23.7% when applied at 1000 µg/mL, 16% when applied at 500 µg/mL, and 16% when applied at 250 µg/mL, compared to the control group. HPLC analysis identified chlorogenic acid as the major component of H. helix. Salvia verticillata L. (Lamiaceae) and Myrtus communis L. (Myrtaceae) treatments resulted in median lifespan extension. Maximum lifespan was extended in worms by Rubus sanctus Schreb. (Rosaceae) treatment. This study provided the first evidence demonstrating the possible lifespan-extending effects of a group of Turkish medicinal plants in an in vivo model, C. elegans.
展开▼
机译：对寿命的研究对于延长寿命和支持健康衰老都很重要。天然产物被广泛利用并用作药物分子的新资源。秀丽隐杆线虫是长寿研究和与年龄有关的疾病的有利生物。在这项研究中，我们测试了许多植物提取物对秀丽隐杆线虫寿命的影响。在寿命测定中，使用不同浓度的植物提取物处理年龄同步的野生秀丽隐杆线虫标本。类似于传统用途，将植物提取物制成滴剂或汤剂。常绿常绿藤（Hedera helix L。）（Araliaceae）以浓度依赖的方式延长了蠕虫的寿命。相比之下，H。螺旋处理组的平均存活率明显提高，分别为23.7％（以1000 µg / mL施用），16％（以500μg/ mL施用）和16％（以250μg/ mL施用）。对照组。 HPLC分析鉴定绿原酸为螺旋藻的主要成分。 Salvia verticillata L.（唇形科）和Myrtus communis L.（桃金娘科）处理导致中位寿命延长。 Rubus sanctus Schreb延长了蠕虫的最大寿命。 （蔷薇科）治疗。这项研究提供了第一个证据，证明在体内模型秀丽隐杆线虫中一组土耳其药用植物可能延长寿命。
展开▼
