Acute toxicity studies of the South African medicinal plant Galenia africana

摘要

class="kwd-title">Abbreviations: DPM, disintegrations per minute; ECVAM, European Centre for the Validation of Alternative Methods (ECVAM); G. africana, Galenia africana; GHS, globally harmonized aystem; GLP, good laboratory practice; HCA, hexylcinnamicaldehyde; LD50, lethal oral dosage; LLNA, local lymph node assay; MTT, methylthiazoldiphenyl-tetrazolium bromide (MTT); NAD, no abnormalities detected; OECD, Organization for Economic Co-operation and Development; PBS, phosphate buffered saline; SI, stimulation index; WHO, World Health Organization class="kwd-title">Keywords: Galenia africana, Acute toxicity, Skin irritation, Episkin, Dermal sensitization, Local lymph node assay class="head no_bottom_margin" id="abs0015title">AbstractBackgroundMedicinal plants are used by a large proportion of the global population as complementary and alternative medicines. However, little is known about their toxicity. G. africana has been used to treat wounds, coughs and skin diseases and is used in cosmetic formulations such as lotions and shampoos.