Towards a standardization of thrombin generation assessment: The influence of tissue factor platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

摘要

BackgroundThrombin generation assay was developed several years ago to mimic physiological coagulation mechanisms but it had important limitations. Thrombogram-Thrombinoscope assay using a fluorogenic substrate, allows obtaining thrombin generation curves in non-defibrinated platelet rich plasma (PRP) in a fully automated manner.