Intrinsic circannual rhythm controls protein dynamics in a hibernator to support rapid heat production

摘要

A proteomics screen of brown adipose tissue in 13-lined ground squirrels reveals protein changes underlying the extreme recruitment and activity cycles characteristic of this organ in small eutherian hibernators. Protein changes precede changes in physiology, indicating endogenous timing rather than ambient temperature controls the annual recruitment-atrophy cycle in this obligate hibernator.