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Insights into Pyrazinamidase and DNA Gyrase Protein Structures in Resistant and Susceptible Clinical Isolates of Mycobacterium tuberculosis

机译：结核分枝杆菌耐药和易感临床分离株中吡嗪酰胺酶和DNA促旋酶蛋白质结构的见解

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Background:Mutations in pncA and gyrA genes cause pyrazinamide (PZA) and fluroquinolone resistance in Mycobacterium tuberculosis (MTB). In the present study, structures of pyrazinamidase (PZase) and DNA gyrase proteins were studied in resistant and susceptible clinical isolates of MTB.

机译：背景：pncA和gyrA基因的突变会引起结核分枝杆菌（MTB）的吡嗪酰胺（PZA）和氟喹诺酮抗药性。在本研究中，在抗性和易感的MTB临床分离株中研究了吡嗪酰胺酶（PZase）和DNA旋转酶蛋白的结构。

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期刊名称 Tanaffos
作者
Azam Ahmadi; Raziyeh Nazari; Mohammad Arjomandzadegan; Mohammad Reza Zolfaghari; Vahideh Vahidi; Toktam Poolad; Manijeh Kahbazi; Maryam Sadrnia; Mojtaba Tousheh; Pourya Rafiee;
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年(卷),期 2016(15),3
年度 2016
页码 147–153
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Mycobacterium tuberculosis Pyrazinamidase DNA Gyrase Protein;

机译：结核分枝杆菌;吡嗪酰胺酶;DNA促旋酶;蛋白质;

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专利

1. Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: Role of mutant DNA gyrase subunits in drug resistance [J] . Suzuki Y., Nakajima C., Tamaru A., International journal of antimicrobial agents . 2012,第5期

机译：耐环丙沙星的结核分枝杆菌临床分离株对氟喹诺酮类药物的敏感性：突变的DNA促旋酶亚基在耐药中的作用
2. Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis. [J] . Mestdagh M, Fonteyne PA, Realini L, Antimicrobial agents and chemotherapy. . 1999,第9期

机译：吡嗪酰胺耐药性，吡嗪酰胺酶活性丧失与结核分枝杆菌多药耐药临床分离株中pncA基因座突变之间的关系。
3. The Structural Modeling of the Interaction between Levofloxacin and the Mycobacterium tuberculosis Gyrase Catalytic Site Sheds Light on the Mechanisms of Fluoroquinolones Resistant Tuberculosis in Colombian Clinical Isolates [J] . N. Alvarez, E. Zapata, G. I. Mejia, BioMed research international . 2014,第18期

机译：左氧氟沙星与结核分枝杆菌促旋酶催化位点相互作用的结构模型揭示了哥伦比亚临床分离株对氟喹诺酮类药物耐药结核的机理。
4. Sequence Analysis of the Gene Region Encoding ESAT-6, Ag85B, and Ag85 C Proteins from Clinical Isolates of Mycobacterium tuberculosis [C] . Ni Made Mertaniasih, Didik Handijatno, Agnes Dwi Sis Perwitasari, International Seminar on Molecular and Cellular Life Sciences . 2016

机译：从结核分枝杆菌临床分离株编码ESAT-6，AG85B和AG85 C蛋白的基因区的序列分析
5. Genomic analyses of Mycobacterium species and clinical Mycobacterium tuberculosis isolates from Utah. [D] . Albert, Heather Ann Hall. 2001

机译：来自犹他州的分枝杆菌种类和临床结核分枝杆菌分离株的基因组分析。
6. Note: Relationship between Pyrazinamide Resistance Loss of Pyrazinamidase Activity and Mutations in the pncA Locus in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis [O] . M. Mestdagh, P. A. Fonteyne, L. Realini, 1999

机译：注意：在耐多药结核分枝杆菌临床分离株中吡嗪酰胺抗性吡嗪酰胺酶活性丧失与pncA基因座突变之间的关系
7. Relationship between Pyrazinamide Resistance, Loss of Pyrazinamidase Activity, and Mutations in the pncA Locus in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis [O] . M. Mestdagh, P. A. Fonteyne, L. Realini, 1999

机译：吡嗪酰胺抗性，吡嗪酰胺酶活性丧失的关系，抗性结核分枝杆菌多药临床分离株中PNCA基因座的突变

Insights into Pyrazinamidase and DNA Gyrase Protein Structures in Resistant and Susceptible Clinical Isolates of Mycobacterium tuberculosis

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