Background. Stroke occurs due to an interruption in cerebral blood supply affecting neuronal function. Body temperature on hospital admission is an important predictor of clinical outcome. Therapeutic hypothermia is promising in clinical settings for stroke neuroprotection. Methods. MEDLINE/PubMed, CENTRAL, Stroke Center, and ClinicalTrials.gov were systematically searched for hypothermia intervention induced by external or endovascular cooling for acute stroke. NIH Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were the main stroke scales used, and mortality was also reported. A meta-analysis was carried out on stroke severity and mortality. Results. Seven parallel-controlled clinical trials were included in the meta-analysis. Sample sizes ranged from 18 to 62 patients, yielding a total of 288. Target temperature (∼33°C) was reached within 3-4 hours. Stroke severity (Cohen's d = −0.17, 95% CI: −0.42 to 0.08, P = 0.32; I2 = 73%; Chi2 = 21.89, P = 0.0001) and mortality (RR = 1.60, 95% CI: 0.93 to 2.78, P = 0.11; I2 = 0%; Chi2 = 2.88, P = 0.72) were not significantly affected by hypothermia. Discussion. Hypothermia does not significantly improve stroke severity; however, this finding should be taken with caution due to the high heterogeneity and limited number of included studies. No impact on mortality was observed.
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机译：背景。中风是由于大脑供血中断影响神经元功能而发生的。入院时体温是临床结果的重要预测指标。在中风神经保护的临床环境中，治疗性体温过低是有希望的。方法。系统搜索了MEDLINE / PubMed，CENTRAL，中风中心和ClinicalTrials.gov，以寻找由外部或血管内冷却引起的急性体温过低的干预措施。 NIH中风量表（NIHSS）和改良的Rankin量表（mRS）是使用的主要中风量表，并且还报告了死亡率。对卒中严重程度和死亡率进行荟萃分析。结果。荟萃分析包括七项平行对照临床试验。样本量从18到62位患者不等，总共288位患者。在3-4小时内达到了目标温度（〜33°C）。脑卒中严重程度（Cohen d = -0.17，95％CI：-0.42至0.08，P = 0.32; I 2 = 73％; Chi 2 = 21.89，P = 0.0001 ）和死亡率（RR = 1.60，95％CI：0.93至2.78，P = 0.11; I 2 = 0％; Chi 2 = 2.88，P = 0.72）低温影响不大。讨论。体温过低不会明显改善中风的严重程度；但是，由于高度异质性和纳入研究的数量有限，应谨慎对待这一发现。没有观察到对死亡率的影响。
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