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Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease

机译：细胞因子治疗优化了脐带间充质干细胞治疗炎性肝病的免疫治疗效果

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BackgroundMesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in clinical trials targeting liver diseases; however the efficacy of MSC therapy will benefit from improvement of the immunomodulatory and immunogenic properties of MSC.

机译：背景间充质基质细胞（MSC）具有免疫调节特性和低免疫原性，这两种特性对于它们发展为有效的细胞免疫疗法都是至关重要的。他们已经在针对肝脏疾病的临床试验中显示出了益处。然而，MSC疗法的功效将受益于MSC的免疫调节和免疫原性性质的改善。

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期刊名称 Stem Cell Research Therapy
作者
Samantha F. H. de Witte; Ana M. Merino; Marcella Franquesa; Tanja Strini; Johanna A. A. van Zoggel; Sander S. Korevaar; Franka Luk; Madhu Gargesha; Lisa O’Flynn; Debashish Roy; Steve J. Elliman; Philip N. Newsome; Carla C. Baan; Martin J. Hoogduijn;
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年(卷),期 2017(8),-1
年度 2017
页码 140
总页数 12
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
关键词
Immunogenic Immunomodulatory Mesenchymal stromal cell Optimising;

机译：免疫原性;免疫调节;间质基质细胞;优化;

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专利

1. Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease [J] . Samantha F. H. de Witte, Ana M. Merino, Marcella Franquesa, Stem Cell Research & Therapy . 2017,第1期

机译：细胞因子治疗优化了脐带间充质干细胞治疗炎性肝病的免疫治疗效果
2. Clinical Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells Transplantation in the Treatment of End-Stage Liver Disease [J] . Xue H. -L., Zeng W. -Z., Wu X. -L., Transplantation Proceedings . 2015,第2期

机译：人脐带间充质干细胞移植治疗终末期肝病的临床治疗作用
3. Effects of inflammatory bowel disease treatment on the risk of nonalcoholic fatty liver disease: a meta-analysis [J] . Lapumnuaypol Kamolyut, Kanjanahattakij Napatt, Pisarcik David, European journal of gastroenterology and hepatology . 2018,第8期

机译：炎症性肠病治疗对非酒精性脂肪肝疾病风险的影响：META分析
4. Intravenous injection of human umbilical cord-derived mesenchymal stem cells for the treatment of sudden sensorineural hearing loss: a case report [C] . Hua Liu, Zhiping Qu, Shanhui Sun, International Conference on Medical Engineering and Bioinformatics . 2015

机译：静脉内注射人脐带源性间充质干细胞，用于治疗突如其来的感官听力损失：案例报告
5. In vitro and in vivo regulation of pro-inflammatory cytokines and drug efflux transporters by signal transduction pathways in glial cells: implications in HIV-1 neuropathogenesis and its treatment. [D] . Ashraf, Tamima. 2015

机译：通过神经胶质细胞中的信号转导途径对促炎性细胞因子和药物外排转运蛋白的体外和体内调节：对HIV-1神经发病机制及其治疗的影响。
6. Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases [O] . Timo Rath, Ulrike Billmeier, Fulvia Ferrazzi, -1

机译：Vedolizumab抗整合素治疗对炎症性肠疾病的免疫途径和细胞因子的影响
7. Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease [O] . de Witte, Samantha F. H., Merino, Ana M., Franquesa, Marcella, 2017

机译：细胞因子治疗优化了脐带间充质干细胞治疗炎性肝病的免疫治疗效果

Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease

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