The trans-well coculture of human synovial mesenchymal stem cells with chondrocytes leads to self-organization chondrogenic differentiation and secretion of TGFβ

摘要

BackgroundSynovial mesenchymal stem cells (SMSC) possess a high chondrogenic differentiation potential, which possibly supports natural and surgically induced healing of cartilage lesions. We hypothesized enhanced chondrogenesis of SMSC caused by the vicinity of chondrocytes (CHDR).