class='kwd-title'>Key Words: biomaterials, devic'/>
A Minimally Invasive Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
class="kwd-title">Key Words: biomaterials, device, hydrogel, pericardial delivery class="kwd-title">Abbreviations and Acronyms: CVD, cardiovascular disease; miRNA, micro-ribonucleic acid; PEG, polyethylene glycol class="head no_bottom_margin" id="abs0020title">SummaryBiomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydrogel delivery and gelation using anatomic structures. The method minimizes risk to patients from embolization, thrombotic occlusion, and arrhythmia. In pigs there were no clinically relevant acute or subacute adverse effects from pericardial hydrogel delivery, making this a translatable strategy to deliver biomaterials to the heart.
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机译：<！-fig ft0-> <！-fig @ position =“ anchor” mode =文章f4-> <！-fig mode =“ anchred” f5-> <！-fig / graphic | fig / alternatives / graphic mode =“ anchored” m1-> class =“ kwd-title”>关键词：生物材料，装置，水凝胶，心包输送 class =“ kwd-title”>缩写和缩写： CVD，心血管疾病； miRNA，微核糖核酸； PEG，聚乙二醇 class =“ head no_bottom_margin” id =“ abs0020title”>摘要生物材料是一种针对心血管疾病的新治疗策略，但很难以安全，准确和可翻译的方式输送到心脏。我们开发了一种通过心包间隙将水凝胶输送至心外膜的方法。我们的设备使用解剖结构为水凝胶输送和凝胶化创建了一个临时隔室。该方法将栓塞，血栓闭塞和心律不齐对患者的风险降到最低。在猪中，心包水凝胶的输送没有临床相关的急性或亚急性不良反应，因此这是将生物材料输送到心脏的可转换策略。
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