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Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status

机译:通过锻炼肌肉收缩力和炎症状态来更新大道

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摘要

Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the “diseasome of physical inactivity”. In contrast, the protective effect of regular exercise against diseases associated with chronic inflammation may to some extent be ascribed to an anti-inflammatory effect. The so called “acute exercise threshold”, the complex mixture of several variables involved in exercise, such as type, volume, frequency, and intensity range is capable of inducing positive physiological adaptations and has been specifically addressed in the recent literature. The major concern is related to the level of the threshold: “exercise training shifts from a therapeutic adaptive intervention to one with potential pathological consequences”. Nonetheless, if the mechanical stimulus is too weak to disrupt cellular homeostasis, training adaptations will not occur. Answering these questions could present practical applications, especially during inflammatory diseases associated with detrimental muscle effects and could theoretically constitute a “new” therapeutic approach to treat/improve an inflammatory state. This paper aims to describe specific data from the literature regarding the effects of exercise on inflammatory diseases in order to promote a more sophisticated perspective on the anti-inflammatory effects of exercise.
机译:缺乏运动会导致内脏脂肪积聚,因此会激活炎症通路网络,从而促进胰岛素抵抗,动脉粥样硬化,神经变性和肿瘤生长。这些情况属于“身体缺乏运动的疾病”。相反,经常运动对与慢性炎症有关的疾病的保护作用可以在某种程度上归因于抗炎作用。所谓的“急性运动阈值”是运动中涉及的多个变量(例如类型,体积,频率和强度范围)的复杂混合,能够引起积极的生理适应,并且在最近的文献中已得到专门解决。主要关注点与阈值水平有关:“运动训练从治疗适应性干预转向具有潜在病理后果的干预”。但是,如果机械刺激太弱而无法破坏细胞稳态,则不会发生训练适应。回答这些问题可能会带来实际的应用,尤其是在与有害的肌肉效应相关的炎性疾病期间,并且理论上可以构成治疗/改善炎性状态的“新”治疗方法。本文旨在描述有关运动对炎性疾病影响的文献中的特定数据,以促进人们对运动的抗炎性作用有更深入的了解。

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