Clozapine is the only antipsychotic with evidence for efficacy in treatment of resistant schizophrenia but it carries a high side effect burden. Patient information is provided but may be poorly retained. This study aims to examine the impact of pharmacist counselling upon patient knowledge of clozapine. Outpatients, aged 18 years and over, attending St. Patrick's University Hospital, Dublin, participated in this study between June and August 2015. The intervention consisted of pharmacist counselling on two occasions one month apart. Knowledge was assessed using a 28-point checklist devised from the currently available clozapine patient information sources, at baseline and after each counselling session. Ethics approval was obtained. Twenty-five participants (40% female; mean age 45.1 years, SD 9.82; 64% unemployed, 28% smokers) showed an improvement in knowledge scores of clozapine from baseline to postcounselling on each occasion with an overall improvement in knowledge score, from baseline to postcounselling at one month, of 39.43%; p < 0.001. This study adds to the evidence that interventions involving pharmacist counselling can improve patient knowledge, whilst the specific knowledge gained relating to recognition of side effects may help patients towards more empowerment regarding their treatment.
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机译:氯氮平是唯一具有抗精神分裂症治疗功效的抗精神病药,但其负担沉重。提供了患者信息,但可能无法很好地保留。这项研究旨在检验药剂师咨询对患者氯氮平知识的影响。 2015年6月至2015年8月间,都柏林圣帕特里克大学医院的18岁及18岁以上门诊患者参加了这项研究。干预措施包括药剂师的辅导,每月两次,两次。在基线和每次咨询后,使用从当前可用的氯氮平患者信息源设计的28分检查表评估知识。已获得道德认证。 25名参与者(女性为40%;平均年龄为45.1岁,标准差为9.82;失业率为64%,吸烟者为28%)在每种情况下均显示氯氮平的知识得分从基线到咨询后均得到改善,知识得分总体从基线提高1个月后的咨询服务占39.43%; p <0.001。这项研究增加了证据,即涉及药剂师咨询的干预措施可以改善患者的知识,而获得的与认识到副作用有关的特定知识可以帮助患者获得更多的治疗权。
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