SA107. Schizotypy in Ultra-High Risk for Psychosis: Its Relations With Basic Symptoms

摘要

>Background: Schizotypy is a multidimensional trait reflecting the vulnerability based on the neurodevelopmental perspective of schizophrenia. The positive dimension including perceptual aberration and magical ideation and negative dimension of social anhedonia were reported to be possible indicators of future psychosis in college students in long-term follow-up studies. The basic symptoms are a substrate-near state from which the first-rank psychotic symptoms will evolve. The basic symptoms of cognitive and perceptual ones are shown to predict the pscyhosis onset in help-seeking clinical populations. The aim of the present study was to explore the relations between schizotypy and basic symptoms in ultra-high risk (UHR) for psychosis individuals using the Chapman’s scale and Frankfurt Complaint Questionnaire(FCQ). >Methods: The sample includes 75 (M 44, F 31) individuals at UHR for psychosis and 75 (M 42, F 33) healthy controls. The diagnosis of UHR was done using the SIPS. The Chapman’s schizotypy scales of perceptual aberration, magical ideation, revised social, and physical anhedonia scale were used. The basic symptoms were assessed using schizophrenia specific items of FCQ (FCQ-S; item number 11, 14, 15, 64, 81, 90, 93, 94). >Results: The sociodemographic profiles were comparable. The perceptual aberration [4.17 (4.13) vs. 8.59 (6.61)], magical ideation [6.72 (4.07) vs. 10.73 (5.96)], physical [11.96 (6.28) vs. 23.93 (10.84)] and social [8.62 (4.84) vs. 22.16 (8.18)] anhedonia, and schizophrenia-specific basic symptoms [0.29 (0.61) vs. 1.76 (1.88)] were significantly higher in UHR for psychosis than healthy controls. Linear regression analysis in UHR group revealed that schizotypy predicted the level of basic symptoms and explained the 35% of the variance (P < .001). The perceptual aberration (beta = .37, P = .004) and magical ideation (beta = .22, P = .102) scale were found to be predictors, respectively. The exploratory factor analysis in UHR group showed that 2 factors had an eigenvalue greater than 1, which collectively represented 75.9% of variance. The first factors represented 48.9% of variance and contained the perceptual aberration (factor loading = 0.87) and magical ideation (0.85) scale and FCQ-S 0.77. The second factor represented 27.0% of variance and contained the physical (factor loading = 0.91) and social anhedonia (0.89) scale. These 2 factors represent the positive and negative dimensions. >Conclusion: The schizophrenia-specific basic symptoms was found to be strong relations with the perceptual aberrations and magical ideation in UHR individuals. This finding suggests that the positive schizotypy may be a vulnerable trait for the development of the schizophrenia-specific basic symptoms in individuals at UHR.