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Resting State Activity and the Stream of Consciousness in Schizophrenia—Neurophenomenal Hypotheses

机译:精神分裂症的静息状态活动和意识流-神经现象假说

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摘要

Schizophrenia is a multifaceted disorder with various symptoms including auditory hallucinations, egodisturbances, passivity phenomena, and delusions. Recent neurobiological approaches have focused on, especially, the abnormal contents of consciousness, the “substantive parts” as James said, to associate them with the neural mechanisms related to sensory, motor, and cognitive functions, and the brain’s underlying stimulus-induced or task-evoked activity. This leaves open, however, the neural mechanisms that provide the temporal linkage or glue between the various contents, the transitive parts that makes possible the “stream of consciousness.” Interestingly, schizophrenic patients seem to suffer from abnormalities specifically in the “transitive parts” when they experience contents as temporally disconnected or fragmented which in phenomenological psychiatry has been described as “temporal fragmentation.” The aim of this article is to develop so-called neurophenomenal hypothesis about the direct relationship between phenomenal features of the “stream of consciousness,” the “transitive parts,” and the specific neuronal mechanisms in schizophrenia as based on healthy subjects. Rather than emphasizing stimulus-induced and task-evoked activity and sensory and lateral prefrontal cortical regions as in neurocognitive approaches with their focus on the “substantive parts,” the focus shifts here to the brain’s intrinsic activity, its resting state activity, which may account for the temporal linkage or glue between the contents of consciousness, the transitive parts.
机译:精神分裂症是一种多方面的疾病,具有多种症状,包括听觉幻觉,egodsturbances,消极现象和妄想。最近的神经生物学方法特别关注意识的异常内容(如詹姆斯所说的“实质性部分”),以将它们与与感觉,运动和认知功能有关的神经机制,以及大脑潜在的刺激诱导或任务相关联。诱发的活动。但是,这留下了在各种内容之间提供时间联系或胶合的神经机制,而传递性成分使“意识流”成为可能。有趣的是,精神分裂症患者似乎经历了暂时断开或碎片化的内容,特别是在“传递部分”中出现异常,这种现象在现象学精神病学中被描述为“时间碎片”。本文的目的是建立所谓的神经现象假说,该假说关于“意识流”,“传递部分”的现象特征与基于健康受试者的精神分裂症的特定神经元机制之间的直接关系。与其像在神经认知方法中强调“实质性部分”那样强调刺激诱发的和任务诱发的活动以及感觉和外侧前额叶皮层区域,不如将注意力转移到大脑的内在活动,即静止状态活动,这可能是由于对于意识内容,传递部分之间的时间联系或胶合。

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