Protein expression of PKCZ (Protein Kinase C Zeta) Munc18c and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)

摘要

BackgroundPolycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder commonly associated with insulin resistance (IR). Previous studies indicate about the expression of molecules involved in the insulin pathway in endometria of women with PCOS-IR. Therefore, the aim of the present study was to evaluate the effect of insulin and testosterone in the expression of these proteins in the endometria and immortal endometrial stromal cell line (T-HESCs).