Role of cervical dendritic cell subsets co-stimulatory molecules cytokine secretion profile and beta-estradiol in development of sequalae to Chlamydia trachomatis infection

摘要

BackgroundChlamydia trachomatis infection of the female genital tract can lead to serious sequelae resulting in fertility related disorders. Little is known about the mechanism leading to Chlamydia induced pathology and factors responsible for it. As only some of the women develops reproductive disorders while majority of the women clears infection without any severe sequalae, mucosal immune response in women with or without fertility disorders was studied to identify factors which may lead to final clinical outcome of chlamydial infection.