Effects of Clozapine Haloperidol and Fluoxetine on the Reversal of Cocaine-Induced Locomotor Sensitization

摘要

ObjectiveRepeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of sensitized behavior, they are ineffective for reversing the sensitized state. We investigated the effect of clozapine, haloperidol, and fluoxetine on the reversal of cocaine-induced behavioral sensitization.