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Differential proteome analysis of human embryonic kidney cell line (HEK-293) following mycophenolic acid treatment

机译：麦考酚酸治疗后人类胚胎肾细胞系（HEK-293）的差异蛋白质组分析

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BackgroundMycophenolic acid (MPA) is widely used as a post transplantation medicine to prevent acute organ rejection. In the present study we used proteomics approach to identify proteome alterations in human embryonic kidney cells (HEK-293) after treatment with therapeutic dose of MPA. Following 72 hours MPA treatment, total protein lysates were prepared, resolved by two dimensional gel electrophoresis and differentially expressed proteins were identified by QTOF-MS/MS analysis. Expressional regulations of selected proteins were further validated by real time PCR and Western blotting.

机译：背景霉酚酸（MPA）被广泛用作移植后的药物，以防止急性器官排斥。在本研究中，我们使用蛋白质组学方法来确定在用治疗剂量的MPA治疗后人胚胎肾细胞（HEK-293）中的蛋白质组变化。 MPA处理72小时后，制备了总蛋白裂解物，通过二维凝胶电泳进行了分离，并通过QTOF-MS / MS分析鉴定了差异表达的蛋白。通过实时PCR和蛋白质印迹进一步验证了所选蛋白质的表达规律。

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期刊名称 Proteome Science
作者
Muhammad Qasim; Hazir Rahman; Michael Oellerich; Abdul R Asif;
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作者单位

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年(卷),期 2011(9),-1
年度 2011
页码 57
总页数 12
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
HEK-293 cells proteome mycophenolic acid drug toxicology differential proteomics;

机译：HEK-293细胞;蛋白质组;麦考酚酸;药物毒理学;差异蛋白质组学;

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1. Differential proteome analysis of human embryonic kidney cell line (HEK-293) following mycophenolic acid treatment [J] . Muhammad Qasim, Hazir Rahman, Michael Oellerich, Proteome science . 2011,第S1期

机译：麦考酚酸治疗后人类胚胎肾细胞系（HEK-293）的差异蛋白质组分析
2. Effects of Methylmercury on Human Neuronal L-Type Calcium Channels Transiently Expressed in Human Embryonic Kidney Cells (HEK-293) [J] . Shuangqing Peng, Ravindra K.Hajela, William D.Atchison The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2002,第2期

机译：甲基汞对人胚肾细胞中瞬时表达的人神经元L型钙通道的影响（HEK-293）
3. Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration. [J] . Jimenez JC, Tyson DR, Dhar S, Plastic and reconstructive surgery . 2004,第2期

机译：人类胚胎肾细胞（HEK-293细胞）：调节神经生长因子释放以促进神经再生的特征和剂量反应关系。
4. Differential Proteome Analysis to the Human Neural Stem Cell [C] . Kun Cho, Gun Wook Park, Jin Young Kim, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：对人神经干细胞的差分蛋白质组分析
5. Mycophenolic acid versus azathioprine in primary immunosuppression for kidney transplant recipients - Systematic review, meta-analysis, and meta-regression. [D] . Wagner, Martin. 2009

机译：麦考酚酸与硫唑嘌呤在肾移植受者初次免疫抑制中的作用-系统评价，荟萃分析和荟萃回归。
6. Cytoproliferative and Anti-Oxidant Effects Induced by Tannic Acid in Human Embryonic Kidney (Hek-293) Cells [O] . Pearl O. Perumal, Priscilla Mhlanga, Anou M. Somboro, 2019

机译：单宁酸在人胚肾（Hek-293）细胞中诱导的细胞增生和抗氧化作用
7. Differential proteome analysis of human embryonic kidney cell line (HEK-293) following mycophenolic acid treatment [O] . Muhammad Qasim, Hazir Rahman, Michael Oellerich, 2011

机译：麦考酚酸治疗后人类胚胎肾细胞系（HEK-293）的差异蛋白质组分析

Differential proteome analysis of human embryonic kidney cell line (HEK-293) following mycophenolic acid treatment

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