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X-ray phase-contrast tomography with a compact laser-driven synchrotron source

机译:紧凑型激光驱动同步加速器源的X射线相衬层析成像

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摘要

Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced––and more challenging––X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches.
机译:在X射线管和大型同步加速器源之间,就X射线束的单色性和亮度而言,在性能上存在很大的差距。但是,由于其尺寸和成本,在中小型学术或工业实验室中,大型同步加速器无法用于更多常规应用。可以通过激光驱动的紧凑型同步加速器光源(CLS)来缩小此间隙,该光源使用红外(IR)激光腔和小电子存储环。硬X射线是在电子束与聚焦激光束相交处通过逆康普顿散射过程产生的。产生的X射线束本质上是单色的,并且高度准直。这使得CLS非常适合于更先进且更具挑战性的X射线成像方法,例如X射线多峰层析成像。在这里,据我们所知,这是第一个成功的示范实验的第一个结果,该实验将来自CLS的单色X射线束用于多峰X射线,即相场,暗场和衰减对比度X射线。断层扫描。我们以小动物(小鼠,离体)的多峰CT扫描形式显示了具有不同液体的流体体模和生物医学应用示例的结果。该结果特别强调了定量多峰CT在激光驱动的CLS的帮助下已经变得可行,并且其结果优于传统方法。

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