Natural Product Synthesis Special Feature: Oligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection

摘要

Controlled formation of oligomeric catechins has become possible by an orthogonal synthetic strategy. Bromo-capping of the C(8) position of the flavan skeleton enabled the equimolar coupling of electrophilic and nucleophilic catechin derivatives, enabling an efficient synthetic strategy to complex catechin oligomers.