首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Multiple Common Properties of Human β2-Microglobulin and the Common Portion Fragment Derived from HL-A Antigen Molecules
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Multiple Common Properties of Human β2-Microglobulin and the Common Portion Fragment Derived from HL-A Antigen Molecules

机译:人β2-微球蛋白和HL-A抗原分子衍生的共同部分片段的多个共同特性

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摘要

11,000-Dalton common portion fragments derived from HL-A antigen molecules were isolated and found to have a significantly high homology to β2-microglobulin in amino-acid composition. Common portion fragments are also very similar to β2-microglobulin with respect to molecular size, charge, and distribution in tissues. Moreover, both are found in the spent culture media of human cell lines and in human plasma and urine. Thus it appears that β2-microglobulin may well be the same substance as the common portion fragment of HL-A antigen molecules.
机译:分离了源自HL-A抗原分子的11,000道尔顿的公共部分片段,发现其在氨基酸组成上与β2-微球蛋白具有非常高的同源性。就分子大小,电荷和在组织中的分布而言,共同部分片段也与β2-微球蛋白非常相似。而且,两者都在人类细胞系的废培养基以及人类血浆和尿液中发现。因此,似乎β2-微球蛋白很可能与HL-A抗原分子的共同部分片段相同。

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